Prisoners coped with their feelings of frustration and powerlessness in a variety of ways. At first, some prisoners rebelled or fought with the guards. Four prisoners reacted by breaking down emotionally as a way to escape the situation. One prisoner developed a psychosomatic rash over his entire body when he learned that his parole request had been turned down. Others tried to cope by being good prisoners, doing everything the guards wanted them to do. One of them was even nicknamed "Sarge," because he was so military-like in executing all commands.

By the end of the study, the prisoners were disintegrated, both as a group and as individuals. There was no longer any group unity; just a bunch of isolated individuals hanging on, much like prisoners of war or hospitalized mental patients. The guards had won total control of the prison, and they commanded the blind obedience of each prisoner.